Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation
نویسندگان
چکیده
منابع مشابه
Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice.
RATIONALE Chronic low-grade inflammation involving adipose tissue likely contributes to the metabolic consequences of obesity. The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue inflammation during obesity is unclear. OBJECTIVE To examine the functional role of IL-33 in adipose tissues and investigate the effects on adipose ...
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Inflammation is a very complicated phenomenon and consist a part of the immune response which is divided to a natural phase followed by an adaptive one. Tissue injury is followed by a cascade of events leading to the inflammatory response which is divided in three phases. The first phase of inflammation is manifested by the activation of the local tissue macrophagues which exert their phagocyti...
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Inflammation is a response to infections or tissue injuries. Inflammation was once defined by clinical signs, later by the presence of leukocytes, and nowadays by expression of "proinflammatory" cytokines and chemokines. But leukocytes and cytokines often have rather anti-inflammatory, proregenerative, and homeostatic effects. Is there a need to redefine "inflammation"? In this review, we discu...
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Tissue factor (TF) is the primary trigger of coagulation. Elevated levels of TF are found in atherosclerotic plaques, and TF leads to thrombus formation when released upon plaque rupture. Interleukin (IL)-33 was previously shown to induce angiogenesis and inflammatory activation of endothelial cells (ECs). Here, we investigated the impact of IL-33 on TF in human ECs, as a possible new link betw...
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ژورنال
عنوان ژورنال: Immunity
سال: 2015
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2015.06.006